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There is a well-recognized phenomenon in gut-hormone pharmacology whereby a signal that potently slows gastric emptying on first exposure gradually loses that particular effect under continuous stimulation, even as its central appetite-suppressing effect persists

(January 2020)

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844 , 845 Dementiafriendly communities were conceptualized in Japan as early as 2004 and have grown into a worldwide movement in the intervening decades

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