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There may be direct pharmacological effects through central GLP-1 pathways, as well as indirect consequences of the medication's intended actions and associated side effects

Moreover, strict quality assurance methods help preserve long-term analytical consistency and dependable laboratory performance

In Table 1, all the principal trials investigating the CV outcomes upon GLP-1RA administration are listed

It is important to mention here that polyphenols cannot cross the blood-brain barrier and may have low bioavailability in the brain, but the intestinal lumen contains them in abundance, and hence, have the ability to modulate the microbiota, which is of utmost importance in the pathogenesis of ASD [197]

Luissint A-C, Parkos CA, Nusrat A (2016) Inflammation and the intestinal barrier: leukocyte-epithelial cell interactions, cell junction remodeling, and mucosal repair

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