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However, this approach to show potential causality has been criticized as it may dissociate the physiological serum-intracellular relationship [26]

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Recommended Dosage: Typically administered from 8 to 10 units per day, divided into two doses: 4-5 units in the morning and 4-5 units in the evening

The complex interplay between silymarin and Kupffer cells adds complexity to understanding its immunomodulatory effects in the context of hepatic inflammation (Gharagozloo et al., 2010)

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