Ministry of Food and Drug Safety
PYY 1875 is an agonist targeting the neuropeptide Y receptor 2 (Y2R)
Triple Agonists (GLP-1/GIP/Glucagon) Class Overview Monograph At a glance Prototype agent / retatrutide (LY3437943), Eli Lilly Mechanism / simultaneous GLP-1R, GIPR, and glucagon receptor co-agonism Phase 2 peak weight loss / up to 24.2% body weight at 48 weeks (retatrutide 12 mg) Primary indications in development / obesity, type 2 diabetes, MASLD/MASH, dyslipidemia Route and frequency / once-weekly subcutaneous injection Key differentiator from dual agonists / added glucagon receptor activity drives hepatic fat mobilization and energy expenditure Most common adverse effects / nausea, vomiting, diarrhea, constipation (dose-dependent) Regulatory status (as of mid-2025) / phase 3 trials ongoing
It lists the compound as a synthetic 15-amino-acid sequence derived from gastric juice, supplied as a sterile lyophilized powder for in vitro study, and it also sells research blends that pair it with other peptides
Each fertility supplement contains a combination of different elements that serve a unique purpose
12 GianniniG.VesciL.MilazzoF