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Once the pigment-producing cells in a follicle are gone, antioxidants can protect the surrounding follicles but may not bring color back to "dead" cells

The following have been shown to shift estrogen metabolism toward the 2-hydroxyestrone pathway[2]: Exercise and weight loss Isoflavones such as soy and flaxseed Omega-3 fatty acids Green tea polyphenol Cruciferous vegetables and broccoli derivatives, including indole-3-carbinol (I3C) and diindolylmethane (DIM, result of I3C after activation by stomach acid) A healthy lifestyle that allows for a normal weight helps to decrease the risk of insulin resistance from metabolic syndrome

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To maintain a steady, endogenous supply of cysteine for glutathione production, the body relies heavily on the transsulfuration pathway

Crucially, the weight loss trajectory at 26 weeks had not plateaued suggesting that longer treatment duration would produce further reductions