For a narrative of how this drug interaction was first serendipitously discovered by David Bailey (a Canadian clinical pharmacologist) (Bailey et al, 2013)
Among various stimuli-responsive silica NPs, disulfide bond-containing NPs show degradability by glutathione reduced form (GSH)
This graduated approach is designed to improve gastrointestinal tolerability, but it also allows the body time to adapt metabolically
Richard Russell Wenwen Wang, 1, * Aihua Mei, 1, * Hang Qian, 1, * Dongfeng Li, 1 Hao Xu, 1 Jishun Chen, 1 Handong Yang, 1 Xinwen Min, 1 Chunlei Li, 1 Li Cheng, 1 Jun Chen 1, 2 1 Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Hubei Key Laboratory of Wudang Local Chinese Medicine Research (Hubei University of Medicine), Shiyan, Peoples Republic of China
The 0.25mg dose delivers enough medication to trigger these metabolic changes while your body adapts to the compound
In people with type 2 diabetes, the body becomes resistant to insulin or doesnt produce enough of it
