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Folate and nucleic acid metabolism The figure highlights that riboflavin in the form of flavin adenine dinucleotide (FAD) is a required cofactor for the enzyme methylenetetrahydrofolate reductase (MTHFR), which reduces 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate
Conversely, some studies show that there is no link between melanotan and melanoma, so chronic activation of MC1R leading to melanoma remains a topic of debate
