Although there is restricted exchange between the cytoplasmic and mitochondrial pools of THF molecules, these compartments are metabolically connected by transport of the one-carbon donors (serine, glycine, and formate) across the mitochondrial membranes
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Therefore, the standardization of measurement and reporting of TL is required in cancer epidemiology before the prognostic value of TL might be accurately evaluated (Adam et al., From the research findings above, it can be concluded that epidemiological associations between TL and age-dependent pathological conditions are often inconsistent and a mechanistic understanding of these associations is still lacking
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