Regardless the type of compound, obesogenic effects are mainly mediated through activation of nuclear receptors (especially PPAR- and RXR), disruption of lipid and glucose metabolism, adipocyte differentiation, inflammation, and altered appetite or satiety regulation
Rehm M, Bruegger D, Christ F, Conzen P, Thiel M, Jacob M, Chappell D, Stoeckelhuber M, Welsch U, Reichart B, Peter K, Becker BF
This water-soluble vitamin is vital for many important bodily functions, including the formation of red blood cells, DNA synthesis, and nerve regeneration
The mechanism appears to involve increased serotonin synthesis in substantia nigra (both compacta and reticulata), a regional pattern unlike any existing antidepressant drug, plus potential dopaminergic contributions given the nigrostriatal location
Anticancer drug discovery based on natural products: from computational approaches to clinical studies
doi: 10.1097/00042737-200411000-00002 20