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Depleting BDNF-TrkB signalling in iSPNs increases GSTO2, leading to AA imbalance and dopaminergic dysfunction by increasing TH-expressing cells

In dopaminergic neurons, tyrosine hydroxylase (TH) catalyzes the addition of a hydroxyl group to the meta position of tyrosine to produce levodopa (L-DOPA) (Meiser et al., 2013)

Many patients drive in from Concord, Lexington, Burlington, and Billerica, or connect through Logan Express before a flight out of Boston

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Regardless, most research applications utilize the injected version, and this is also the form that is most often used in both research and clinical settings

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