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In a twist, the study found that although there was a small increase in diabetic retinopathy, GLP-1 use appeared to protect against the conditions progression and sight-threatening complications

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The first three might be considered first choice by doctors, they write, although the two most effective drugs amitriptyline and venlafaxine might still be first choice for severe depression

Treatment response and tolerability should be considered when selecting the maintenance dosage

Individual Response Variability and Biomarker Considerations Not all patients respond identically to tirzepatide