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In ITT analysis the GLP-1 RA vs DPP-4 inhibitor cohort median follow-up was 2 years [14] for GLP-1 RAs users and 4 years [27] for DPP-4 inhibitor users

These mechanisms collectively improve glycemic control in patients with type 2 diabetes

McLeod provided Banting with laboratory facilities, some experimental dogs and the assistance of Charles Best, a research student

10.1111/BPH.14019 110 NaefM.RussmannS.Petersen-FelixS.BrenneisenR

The enzyme dipeptidyl peptidase 4 (DPP-IV) cleaves it between the second and third residues which renders it inactive within several minutes, and explains why GLP-1 cannot be used as a drug itself

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