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Patients with known liver disease, history of gastrointestinal bleeding, or those taking anticoagulant or antiplatelet medications face higher risk for significant bleeding complications and should have a lower threshold for seeking emergency care

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Cell viability Cell viability was determined by the CCK8 method according to the manufacturers protocol

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This figure is remarkable in the context of GLP-1 therapeutics: oral semaglutide (Rybelsus), despite incorporating the SNAC absorption enhancer, achieves oral bioavailability of only 0.4-1.0%, meaning that more than 99% of the ingested semaglutide peptide is lost to gastrointestinal degradation and poor absorption