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A recent report from the Institute for Clinical and Economic Review, an independent nonprofit that evaluates the value of medical treatments, found that GLP-1s such as Ozempic, Wegovy and Zepbound are cost-effective, meaning the medications health benefits justify their price

But it may also be a signal that something deeper is being left untreated

Its a strong fit for people who want medical treatment with flexibility

They found widespread associations with benefits to cognitive and behavioral health, while also revealing increased risks for pancreatitis and kidney conditions, among others

The evidence hierarchy runs: prescription GLP-1 medication (strongest), oral supplements at studied doses (modest), dietary changes supporting natural GLP-1 (helpful), adhesive patches (zero evidence)

doi: Garabadu D, Verma J (2019) Exendin-4 attenuates brain mitochondrial toxicity through PI3K/Akt-dependent pathway in amyloid beta (142)-induced cognitive deficit rats