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For example, BDNF has been implicated in craving and seeking-related behaviors in preclinical studies, with periods of cocaine abstinence that are characterized by high BDNF levels during craving episodes

It has been traditionally thought that exogenous GABA (i.e., taken as a supplement) does not cross the bloodbrain barrier, but data obtained from more recent research (2010s) in rats describes the notion as being unclear

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