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Coniferyl ferulate blocks the NMDAR/NR2B-CaMKII-MAPKs signaling pathway, inhibits ROS production and mitochondrial apoptosis, while reshapes the intestinal microbiota and microbial metabolism, ameliorates colonic inflammation and alleviates depressive symptoms in mice

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Research published in PNAS in 2013 found that Akkermansia supplementation in obese mice increased gut levels of endocannabinoids that control inflammation, glucose metabolism, and gut barrier integrityfactors that influence GLP-1 secreting cells