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Research Evidence Comparison# CagriSema Research# The REDEFINE Phase 3 program provides robust evidence: REDEFINE 1 (3,417 participants, 20.4% weight loss at 68 weeks) and REDEFINE 2 (1,200 T2D participants, 13.7% weight loss)

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Wegovy, a brand name of semaglutide, has been associated with these side effects: Nausea and vomiting Diarrhea or constipation Stomach pain or indigestion Decreased appetite leading to weight loss Fatigue and dizziness Increased heart rate Insomnia (difficulty sleeping) In rare cases, patients may also experience: Tremors and feelings of anxiety or nervousness

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Cardiovasc Diabetol 21(1):232 Hu Y et al (2022) Cost-effectiveness analysis of 4 GLP-1RAs in the treatment of obesity in a US setting