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This clearance mechanism has also been described in the context of different cellular stressors leading to PS exposure, e.g., hyperosmotic stress [217], plasmodium infection [77], oxidative stress [72], and, to some extent, also ageing of erythrocytes [218]

Biomark Res

However, it has also been pointed out the NO and peroxynitrite formation can be stimulated in mammalian spermatozoa using D-arginine, which cannot be a substrate for NOS

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As shown in Section Riboflavin Ameliorates Oxidative Stress, Mitochondrial Dysfunction, and Neuroinflammation, riboflavin has antioxidant properties and upregulates antioxidant enzymes especially SOD, also, supplementation with riboflavin will elevate the intra-mitochondrial FAD levels compensating for the decline in the capacity to assemble of dysfunctional mitochondrial complexes

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