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As previously mentioned, GLUD1 stability is regulated by methylation and ubiquitination
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In human thyroid cancer, GPx3 is frequently methylated, and the expression of GPx3 is regulated by methylation of the promoter region, and this methylation is related to tumor size and lymph node metastasis through the inhibition of Wnt/-catenin signaling [100]
Anti-diabetic activity in type 2 diabetic mice and -glucosidase inhibitory, antioxidant and anti-inflammatory potential of chemically profiled pear peel and pulp extracts ( Pyrus spp.)