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iodine uptake, thyroid hormone production, interconversion of thyroid hormones, cellular uptake and cell receptor activation

They are likely related to complex downstream metabolic dysregulation induced by the disruption of incretin signaling rather than a proobesity effect of GLP-1 per se (94)

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Endnotes: The efficacy estimand represents efficacy had all randomized participants remained on study intervention (with possible dose interruptions and modifications) without initiating prohibited weight management treatments (and glycemic rescue therapy for glycemic endpoints only)