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Ketone bodies are known to be generated from acetyl-CoA when a large amount of acyl-CoA remains unmetabolised following the TCA cycle

For example, in a 2021 study, as little as 100mg of dihydroberberine increased berberine blood levels better than 500mg of HCl, and another 2021 study (by Indena, the company that makes Berbevis) found that a phytosomal preparation resulted in a tenfold improvement in bioavailability compared with HCl.48 51 Based on these studies, you might conclude that the two bioenhanced forms are superior to berberine HCl

Freitas S, Merkle HP, Gander B

This makes it a safer alternative for those seeking skin lightening products that won't compromise skin health

Carcinogenesis 23(10):16611665 Sheen L-Y, Chen H-W, Kung Y-L, Liu C-T, Lii C-K (1999) Effects of garlic oil and its organosulfur compounds on the activities of hepatic drug-metabolizing and antioxidant enzymes in rats fed high-and low-fat diets

Treat Respir Med