However, dedicated studies are needed to test the translatability of the preclinical data of amylin and calcitonin dual agonism and to delineate the separate and combined physiological effects of amylin and/or calcitonin receptor activity in humans
Cagrilintide is a long-acting analogue of amylin, a hormone naturally co-secreted with insulin from the pancreatic beta cells
References Kanner, L
Oley.org
A generic berberine or garcinia extract cannot account for your individual peptide-pathway variations that determine appetite regulation, insulin sensitivity, and metabolic rate
SS-31 may also inhibit the opening of a channel in the inner membrane called the mitochondrial permeability transition pore (mPTP), at least in rodents.5 Because mPTP opening has been implicated in neuronal death, SS-31s inhibitory action is a potential mechanism of action for the peptides cognitive health benefits.6 Furthermore, several studies have concluded that SS-31 is capable of scavenging mitochondrial reactive oxygen species, making it a potent antioxidant.19 Its antioxidant mechanism of action isnt yet fully understood, but one group of researchers has theorized that it has to do with an ability to activate autophagy20 a cellular recycling process that promotes efficient function and which is critical for mitigating oxidative stress.21 Current therapeutic uses of SS-31 Clinical studies on SS-31 support its use as a treatment for multiple aging-related changes, including those related to cognition, physiology, and vision
