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While the top of TM6 and ECL3 could not be confidently modelled for the exendin-4 complex, the portion of TM6 and TM7 that were modelled, along with the weak density corresponding to ECL3 supports a backbone conformation more similar to GLP-1 and oxyntomodulin bound receptors, rather than exendin-P5, albeit it is likely that this region is more conformationally dynamic

Meanwhile, semaglutide's influence on insulin secretion means your blood glucose may dip lower than expected, especially if alcohol is consumed without food

Zhang Z, Takahashi S, Saito S, Koizumi T

Weekly physician follow ups available in clinic or by telehealth

Semaglutide has been a game-changer for people with type 2 diabetes