It is also not yet known whether such dysbiosis leads to ME/CFS, or whether it is a consequence of the metabolic and immunologic changes that occur in the disease (201)
Low IGFBP2 is linked to metabolic syndrome and insulin resistance, whereas higher IGFBP2 is associated with lower fasting glucose and insulin but increased mortality in older adults, independent of CRP and IL-6 [154, 155]
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GLP-1RA use was also associated with a lower risk of mortality and ED visits, while hospitalization was not significantly reduced
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