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Combination dosing produced greater reductions in body weight than semaglutide alone over 20 weeks, with a tolerability profile broadly consistent with each component

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Retatrutide simultaneously activates GLP-1, GIP, and glucagon receptors, distinguishing it from licensed agents such as semaglutide or tirzepatide

Research suggests this coordinated signaling can produce more consistent GH pulses, enhance the precision of GH-related assays, and provide a broader view of metabolic, lipolytic, and regenerative mechanisms than either compound individually

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