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Eroglu et al

If the results do not allow for the precise identification of a genetic aetiology, and, still, the age of onset, extrahepatic manifestations, and family history of jaundice or ICP all point towards inherited cholestasis, a thorough investigation such as WES allows a high percentage of patients to reach a diagnosis

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Gating strategies are depicted in Supplementary Fig

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Thyroid-related palpitations may be accompanied by other symptoms like weight changes, temperature sensitivity, fatigue, or changes in bowel habits