The effects of GLP1(736) on cells may also be indirect, mediated through insulin and glucagon released by and cells, respectively, which can alter somatostatin secretion
Common gastrointestinal side effects include: Nausea and vomiting Diarrhoea or constipation Abdominal pain and bloating Reduced appetite Indigestion These effects typically diminish as the body adjusts to the medication, usually within several weeks
While semaglutide GLP-1 offers promising results, the choice of GLP-1 medication should be individualized
If it is approved, Ryan said it will be important to monitor the drug for safety in the real-world population during the postmarketing surveillance period, as real-world populations differ from people enrolled in a clinical trial
Historically, GLP-1 receptor agonists were firmly embedded within endocrinology
doi: 10.1016/S2213-8587(19)30194-9 21 ZinmanBArodaVRBuseJBCariouBHarrisSBHoffSTet al