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When NAPQI levels are higher than the livers capacity to neutralize, NAPQI will form protein adducts on the mitochondria of liver cells
10.1017/S0007114507257770 Martin FPJ, Wang Y, Yap IKS, Sprenger N, Lindon JC, Rezzi S, Kochhar S, Holmes E, Nicholson JK: Topographical variation in murine intestinal metabolic profiles in relation to microbiome speciation and functional ecological activity