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While the methyl cycle requires the essential nutrients methionine, folic acid (for CH 3 -THF), and choline (as a precursor of betaine), SAM is itself not considered one

Chemistry 27(7):22892293

However, its important to listen to your body and assess whether you feel able to continue with the protocol

Continue with lifelong intramuscular injections, even if symptoms have improved or are no longer present 1 Frequency The frequency of injections varies from country to country

The molecular structures of representative active compounds are presented in Table 2

The exact timing depends on the patients needs, like how severe the deficiency is and how well they absorb the vitamin