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The main concerns with GLP-1 agonist drugs include: GI side effects (nausea, diarrhea, vomiting, constipation, abdominal pain) High out-of-pocket cost for those who do not quality under insurance Risk of inadequate nutrition (reduced intake + insufficient nutrition counseling) Significant loss of muscle mass & bone density High discontinuation rates (with lost weight regained) Limited public & clinician knowledge on importance/implementation of nutrition and lifestyle changes Side Effects and Costs of GLP-1 Medications The use of GLP-1 drugs has been associated with numerous side effects, ranging from mild to severe

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of the oil in place of butter increased GLP-1 43% within a single day