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Neuregulin and IGF1 can act synergistically to increase mitochondrial biogenesis and mtDNA replication in primary Schwann cells, which requires both the ERK and PI3K signaling pathways (Ribeiro et al., 2014)

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Abstract Alzheimers disease (AD) is a multifactorial neurodegenerative disorder described as progressive cognitive decline and neuronal dysfunction, affecting millions globally

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