glp-1 benefits and risks Do The of Drugs OutWeigh the Negatives? Bariatric Surgery Vs. GLP-1: Which

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Nesta abordagem individualizada e adaptada, os aGLP-1 so recomendados para pacientes fora do alvo glicmico com alto risco de desenvolvimento de doena cardiovascular, necessidade de perda ponderal e/ou meta de reduzir risco de hipoglicemia

While most patients initially achieve remission, approximately 30-80% of patients experience CD19-positive relapse 1 , highlighting the need to improve therapeutic efficacy

A great deal of GLP-1 signaling happens through the nervous system L-cells activate sensory neurons in the gut wall, and GLP-1 receptors in the brain govern satiety

This is probably related to the drugs incretin effect.20 The demonstrated potential of SEMA to reduce adipose accumulation at the lingual level may represent an additional mechanismbeyond weight lossfor improving the control of sleep apnoea.22 The SCALE programme also demonstrated the ability of LIRA 3 mg to improve cardiovascular risk factors (CVRFs), including blood pressure, lipid profile and inflammation markers.13 The effects on glycaemic control and CVRFs associated with SEMA 2.4 mg in the STEP programme are qualitatively similar, but quantitatively superior to those observed with LIRA 3 mg, possibly related to the different weight loss.16 The SELECT study, conducted with SEMA 2.4 mg, consistently showed a reduction of major adverse cardiac events (MACE) of triple composite endpoint (non-fatal myocardial infarction, non-fatal stroke, cardiovascular mortality) of 20% relative to placebo in a population with established cardiovascular disease and BMI greater than 27 kg/m2 without diabetes after 39.8 months of follow-up.23 Although a direct role of SEMA cannot be ruled out, the influence of adipose reduction and the improvement of adipocyte dysfunction probably contribute to the evolving profile of cardiovascular risk factors

Les effets secondaires ventuels restent rares et gnralement bnins : lgers troubles digestifs (ballonnements, petites crampes abdominales), surtout en dbut de cure