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It's worth noting that while lean mass decreases in absolute terms, the proportion of lean mass relative to total body weight may be maintained or slightly increase, as fat mass typically falls more rapidly

Patients typically experience severe nausea and vomiting within 26 hours of an overdose, followed by persistent abdominal pain, constipation, or diarrhea lasting days

doi:10.1038/s41467-019-10713-z

Fat and protein slow gastric emptying further, compounding the nausea effect

The relationship of ghrelin and adiponectin with bone mineral density and bone turnover markers in elderly men

Dosing adjustments for women vs men Women need different approaches than standard protocols