doi: 10.1097/JW9.0000000000000003
The discrepancies between experiment and theory throughout the long history of vitamin B12 research are caused by the significant influence of the pseudo-Jahn-Teller effect on its biochemical processes, which cannot be accounted for by either the standard density functional theory (DFT) method [88] or the QM-DFT approximation used in most quantum mechanics/molecular mechanics (QM/MM) studies [2, 89]
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9 BokowskiL.SobaniecW.elazowska-RutkowskaB
A previous analysis by Jeong et al
114,220,223,224,225 Different CBS inhibitors have been designed and tested over the past years, starting with amino-oxyacetic acid (AOAA) 52,58,60 and related prodrugs