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In summary, these data not only show that GIPR antagonism and GLP-1R agonism act on the same neuronal populations in the DVC, but also that they similarly downregulate gene programmes implicated in synaptic plasticity and synapse formation

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The SURMOUNT-1 study was a placebo-controlled 72-week trial in obese subjects that randomized 2,539 participants without diabetes into four equally large study arms with placebo or one of the three tirzepatide doses (5, 10, or 15 mg once weekly)