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Subsequent clinical studies with liraglutide and semaglutide confirmed these findings, and further demonstrated the effect to be mediated via reduced energy intake

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GIP and GLP-1 are the key incretin hormones released from the intestine in response to food intake, particularly glucose and other nutrients, stimulating insulin secretion from the pancreas

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Replacing these with whole grains, legumes, and vegetables preserves the medication's mechanism of action and delivers sustained energy