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For perspective on where this lands against the field (placebo-adjusted weight loss): Type 2 diabetes TRANSCEND-T2D-1 (n = 537, 40 weeks) Published simultaneously in The Lancet

doi: 10.2460/javma.232.8.1200

Results GEP44 binds to and activates GLP-1R, Y1-R, and Y2-R via biased agonism The addition of GEP44 to H188-GLP-1R transduced HEK293 cells resulted in elevated levels of cAMP with an EC 50 value of 417 pM (Fig

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The ingredients in GLP-1 patches have primarily been studied when taken orally, with little to no high-quality evidence that transdermal versions deliver comparable amounts or effects