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Effect of renal insufficiency on the pharmacokinetics of sitagliptin, a dipeptidyl peptidase-4 inhibitor

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von Joest M, Chen C, Douch T et al (2022) Amphiregulin mediates non-cell-autonomous effect of senescence on reprogramming

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Instead of binding to microtubules, hyperphosphorylated tau aggregates to form insoluble fibrils, which accumulate within neurons forming NFTs, one of the defining pathological features of AD and commonly associated with neurodegeneration in general 32