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When there are reduced levels of PTH in the circulation the CYP24A1 gene is active leading to the stimulated synthesis of the inactive 24,25-(OH) 2 D 3

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53,54 However, it has also been suggested that the enhanced release of proinflammatory cytokines (TNF-, IL-1, IL-6, and IL-10) and chemokines (monocyte chemoattractant protein-1, macrophage inflammatory protein-2, and IL-8) further promotes hepatocyte damage, thereby aggravating necrosis