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This antioxidant activity is vital because excessive ROS can impair mitochondrial function, leading to oxidative stress and affecting the energy production of neurons and glial cells, potentially causing migraine headaches ( Vitamin B2 deficiency disrupts intermediary metabolism, potentially impairing energy production via the ETC, which is mainly concerned for the nervous system, given its high energy demands, and also can lead to disorders, such as migraine, because of energy failure, alongside overproduction of ROS (47)

Glutathione is the most important antioxidant in the human body

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Nanoencapsulation techniques for compounds and products with antioxidant and antimicrobial activity-A critical view