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Some cases are recorded, but there are a few things to consider

While systemic injection also delivers peptides to the brain via blood circulation, nasal delivery may provide more direct CNS access for some portion of the dose

Diabetic peripheral neuropathy evidence A mouse model study specifically examining Cerebrolysin effects on diabetic peripheral neuropathy produced dose-dependent results

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However, efficacy against severe disease does appear more durable, with vaccines leading to a ~90% reduction in severe disease at 5 months postvaccination [30, 33]