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Garg R, Williams GH, Hurwitz S, Brown NJ, Hopkins PN, Adler GK

Pancreatic peptides and amylin Meal termination may be attributed to the action of endogenous amylin and glucagon since receptorial antagonists or specific antibodies increase food intake

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A meta-analysis of adults with knee OA and obesity found that a 5% to 10% weight loss significantly improved pain, self-reported disability, and physical quality of life ( 5.4 Positioning GLP-1 receptor agonists among obesity-treatment options GLP-1 receptor agonists should be positioned within the broader continuum of obesity treatment rather than presented as a replacement for existing strategies