Upon activation, NLRP3 engages the scaffold protein NIMA related kinase 7 (NEK7) and recruits the adaptor apoptosis-associated speck-like protein containing a CARD (PYD and CARD domain containing (PYCARD, also known as ASC)) to assemble the inflammasome complex
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et al., Diabetes/Metabolism Research and Reviews 2
If hair shedding begins three to six months after starting GLP-1 therapy and is diffuse rather than patchy or patterned, GLP-1 related telogen effluvium is the most likely cause
Preclinical animal studies, in vitro mechanistic investigations, and human clinical studies were eligible