It has been demonstrated that fasting and calorie restriction significantly increased the expression of OCTN2 and carnitine concentrations in the muscular tissues, liver and kidney [36]
For instance, investigations into defective immunometabolism in CF macrophages have utilized the Seahorse Extracellular Flux analyzer, revealing impaired oxygen consumption, both at baseline and following infection with challenging pathogens like Burkholderia cenocepacia (Hamilton et al., 2021)
10.1021/acsomega.0c01778 43 LushchakO.StrilbytskaO.KoliadaA.StoreyK
Aberrations in carnitine regulation are implicated in complications of diabetes mellitus, hemodialysis, trauma, malnutrition, cardiomyopathy, obesity, fasting, drug interactions, endocrine imbalances and other disorders
Outcomes are individual
Lipids and oocyte developmental competence: the role of fatty acids and beta-oxidation