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It is well known that free radicals or ROS play critical roles in the development of various chronic diseases, including aging, heart disease, and cancer (Glin et al

There were no adverse maternal or offspring effects in rats treated throughout organogenesis and lactation with 1.5 mg/kg/day phentermine and 10 mg/kg/day topiramate (approximately 2- and 3-times clinical exposures at the MRHD, respectively, based on AUC)

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