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Long-Term Results: Six Months and Beyond Clinical trials demonstrate that sustained use of GLP-1 medications over twelve to eighteen months can produce average weight loss of fifteen to twenty percent of starting body weight

The ingredients are generally recognized as safe (GRAS) and have long histories of dietary use, but the specific formulation is relatively new

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These medications work through distinct mechanisms: DPP-4s slow the breakdown of incretin hormones, while GLP-1 agonists directly activate GLP-1 receptors