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But this makes hitting protein targets extremely difficult

Experimental doses in humans have ranged from 2-5mg administered twice weekly subcutaneously

Day 1-2 (Acute Detoxification) Internal systemic detoxification biologically peaks

Most common side effects resolve predictably: nausea (often subsides by week 34), vomiting (usually resolves by week 6 if dose escalation is appropriate), constipation (may persist longer, typically 812 weeks, but manageable with hydration and fiber), and appetite suppression (intentional effect that normalizes as you reach maintenance dose)

Topical applications and certain delivery methods can improve its effectiveness