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In one trial, around 800 people received weekly semaglutide injections accompanied by dietary adjustments, a prescribed exercise regime and psychological counselling, all of which helped them to lose nearly 11% of their starting weight over four months

To replicate the situation where efficacy predictions are made before treatment, we assumed the dose, treatment duration and drug type variables were unknown, and imputed these values in the model to an arbitrary constant value for all participants

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Document any adverse effects, including timing, severity, and associated factors, to facilitate clinical assessment

Equally important is the urgent need to design societal health responses able to better identify, prevent and manage the disease (WHO 2023)

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