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Zepbound was FDA-approved in 2023 for long-term weight management in adults with obesity (with a body mass index of 30 or higher) and overweight (with a body mass index of 27 or higher) with at least one weight-related condition, such as high blood pressure, type 2 diabetes, or high cholesterol

Some doctors suggest staying at 2 mg and optimizing diet and exercise

Non-diabetic users may use GLP-1 medicines for medically supervised weight management if they meet clinical criteria

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Personal or family history of medullary thyroid cancer, Multiple Endocrine Neoplasia syndrome type 2, history of severe pancreatitis, active gallbladder disease, pregnancy or plans to become pregnant, severe gastrointestinal disease

Your prescribing physician must document previous weight loss attempts, including dates, methods, and outcomes