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Figure 3: Structure of the pancreas with Islet of Langerhans, credit: BruceBlaus, Wikimedia Knowledge about the pancreas deepened further as a result of research by Ernest Starling and his brother-in-law William Bayllis, two British physiologists at UCL

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Clinical Evidence: What the Data Shows Phase 3 Trial Results (Zepbound Studies) The REFRAME and related trials demonstrated: Weight Loss Average: 22.5% body weight reduction at 68 weeks Range: 18-28% depending on population Significantly exceeds tirzepatide (21% at comparable doses) Body Composition Preferential loss of visceral fat (the dangerous kind) Better preservation of lean muscle vs

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